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Title authors
A Systematic Review and Meta-Analysis of Randomized Controlled Trials on the Use of Fire Needle Therapy for Moderate-to-Severe Acne: Comparing Efficacy, Recurrence Rate, and Adverse Effects
Background
Moderate to severe acne is typically managed with isotretinoin or antibiotics as first-line treatments; however, these drugs are associated with significant side effects. In contrast, fire needle therapy, widely practiced in China, has shown promising clinical efficacy for moderate-to-severe acne, exhibiting fewer adverse effects that allow it to serve as a primary therapeutic option or be used in conjunction with pharmaceutical medications.
Methods
A systematic review was conducted using comprehensive databases like PubMed, Embase, Cochrane Central Register of Controlled Trials, CNKI China Network Knowledge Infrastructure, SinoMed China Biomedical Literature Service System, CQVIP China Science and Technology Journal Database, and Wanfang Data Knowledge Service Platform from their inception date to November 22, 2018. We med to identify randomized controlled trials comparing fire needle therapy alone or in combination with Chinese herbs or conventional pharmaceuticals agnst standard treatment for moderate-to-severe acne.
Data Analysis
RevMan 5.3 software was employed to calculate the risk ratio RR and its corresponding 95 confidence interval CI. Data from eligible studies were pooled using a fixed-effect model when the I2 statistic was below 50, or a random-effects model when I2 exceeded this threshold.
Results
A total of ten trials with a combined participant count of 904 met our inclusion criteria. Meta-analyses revealed that fire needle therapy in combination with clindamycin or oral isotretinoin had superior efficacy compared to standard pharmaceutical treatment RR = 2.18; 95 CI: 1.19, 3.99; P 0.03 under the random-effects model; I2 = 72. Fire needle therapy alone was also found to be more effective than pharmaceutical medications in treating moderate-to-severe acne RR = 2.32; 95 CI: 1.77, 3.03; P 0.00001 under the random-effects model; I2 = 59. No significant difference was observed between recurrence rates among fire needle and pharmaceutical treatment groups RR = 0.78; 95 CI: 0.54, 1.14; P = 0.20 using a fixed-effect model with an I2 of zero. Furthermore, adverse events associated with fire needle therapy were limited to transient sensations like burning and tingling.
Fire needle therapy, either as monotherapy or in combination with other treatments, demonstrates efficacy for moderate-to-severe acne management. However, additional large-scale, rigorously designed clinical trials are warranted to validate these findings conclusively.
Keywords: Fire needle; Moderate-to-Severe Acne; Pharmaceutical Medications; Systematic Review
Copyright ? 2019 Elsevier Ltd. All rights reserved.
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Fire Needle Therapy for Acne Treatment Moderate to Severe Acne Management Pharmaceutical Medications vs. Traditional Methods Systematic Review of Acne Trials Efficacy and Adverse Effects Comparison Combination Therapy for Severe Acne